Cancer Lipid Metabolism, Lipoprotein A And Prostate Cancer Risk: Prostate cancer risk may be linked to genetic variants associated with higher levels of lipoprotein in the bloodstream, according to a new study.
Cancer Lipid Metabolism, Lipoprotein A And Prostate Cancer Risk
Some risk factors for prostate cancer, such as older age and African-American ancestry, cannot change. Smoking and obesity, for example.
May be modifiable risk factors for the aggressive form of the disease. Previous studies have linked higher levels of lipids in the blood to an increased risk of cardiovascular disease.
If this is the case, lipid-lowering drugs may be able to lower the risk of prostate cancer. Blood lipids have been link to prostate cancer in some studies. But the results have been mix.
The possible links between prostate cancer risk and a number of blood lipids. lipoprotein A, LDL-cholesterol and HDL cholesterol, triglycerides and A and B.
A technique known as Mendelian randomization is employ to increase the validity of the findings. This method makes use of the inherent randomness of the meiotic genetic process.
As a result, rather than relying on blood tests to determine a person’s lipid levels. The researchers look at genetic variations associate with varying lipid levels in the blood.
If these genetic variants are statistically link to an increased risk of prostate cancer. They investigated further.
There are genetic variants associate with a greater risk of advanced or early-onset prostate cancer. As well as with a greater risk of overall prostate cancer, according to the study.
None of the other blood lipids are find to have a significant correlation with the results of the study.
Lipoprotein A-lowering drugs may develop or repurpose to reduce the risk of prostate cancer in some individuals base on these findings.
More research is required to confirm the findings of this study and to clarify the biological mechanisms that underlie them.
There may be an increased risk of developing prostate cancer in men who have elevated plasma concentrations of lipoprotein A. That is a protein that transports cholesterol through the bloodstream.